Sentence examples for modelling studies suggested from inspiring English sources
Energy minimisation modelling studies suggested that two mutations, T246G and I240A, would allow the enzyme to utilise l-mandelic acid as a substrate.
Modelling studies suggested that the introduction of a NH linker between the P3 aryl and P2 leucinamide moieties would allow the formation of a H-bond with the Gly66 residue of Cat K, hopefully increasing potency.
The results showed carboxypeptidase Y, hog liver esterase and crude CEM tumor cell extracts to hydrolyse the ester motif of phosphoramidates with subsequent loss of the aryl group, while molecular modelling studies suggested that the AraU l-alanine aminoacyl phosphate derivative might not be a good substrate for the phosphoramidase enzyme Hint-1.
Both empirical and mathematical modelling studies suggested that this concentration should be sufficient to induce coagulation [25].
Our molecular modelling studies suggested that PETIM-DG's antagonist activity depended upon the formation of co-operative electrostatic interactions with two key residues that line the entrance to MD-2's hydrophobic pocket; the first is Ser to which the 4′-phosphate on the diglucosamine of Lipid A binds, and the second is Tyr to which TLR4 binds.
A recent meta-analysis, largely based on US modelling studies, suggested that for every 1% increase in price, energy intake would reduce by 0.02%.
Moreover, modelling studies suggest that treatment of active PWID could control the burden of HCV in this population by decreasing the viral load among current drug injectors and reducing transmission rates [ 17].
A 2013 cost-effectiveness modelling study suggested that screening with Epi proColon every two years would be less effective and more costly than the alternatives.
A crystal structure of an Fc fragment with the mutations S239D/A330L/I332E was solved and modeling studies suggested that additional hydrogen bonds, hydrophobic contacts, and/or electrostatic interactions resulted in enhanced binding to FcγRIIIa (Oganesyan et al., 2008).
The crystal structure of the mutated Fc was solved and modeling studies suggested that conformational changes at P329 would not be favorable for formation of the "proline sandwich" and changes at D270 could negatively impact C1q interactions.
Previous homology modeling studies suggested that YfiB contains a Pal-like PG-binding site (Parsons et al., 2006), and the mutation of two residues at this site, D102 and G105, reduces the ability for biofilm formation and surface attachment (Malone et al., 2012).
