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Molecular modelling studies show that 15a and 16a bind in the same domain as that of cryptophycins.
Our modelling studies show conservation of core residues in the Cry8Ka5 toxin structure, suggesting that the mutations altering activity should not affect molecular stability.
However, while the modelling studies show good agreement between predicted P uptake and measured P uptake in soil-grown plants (Kirk et al., 1999 b ), it is worth noting that no direct cause and effect relationship between LMWOA efflux and P uptake has been shown for upland rice.
Cost-effectiveness studies and modelling studies show that cervical screening may become much more efficient in terms of decreasing numbers of false-negative and false-positive smears, if a test is used with a substantial higher sensitivity and long-term NPV than conventional cytology (Canfell et al, 2004).
Modelling studies show that existing strategies alone are not sufficient to achieve the 2050 target of elimination of TB as a public health concern, and that new strategies for prevention (e.g. new tools for diagnosis and new vaccines, particularly new vaccines that both prevent infection and disease progression), and treatment (e.g. shorter, more effective regimens) are needed [ 15- 17].
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Molecular modelling studies showed that five of the isolated compounds showed physicochemical properties that completely within the recommended range for more that 95%% of known drugs, while two compounds have only one violation.
Preliminary modelling studies showed that α- l-fucosidases iso1 and iso2 have a common TIM-barrel protein fold and retaining mechanism of action.
Theoretical modelling studies showed that highly connected persons get infected earlier and more often and play a more important role as infectors than rather isolated persons [ 88, 89].
Recent modelling studies showed that such a coupling of fluxes is an important behaviour of biological systems e.g. with respect to co-regulation of genes [ 14].
Recent structural and molecular dynamics based modelling studies showed that the ErbB3 pseudokinase domain uses an alternative phosphotransfer mechanism to transautophosphorylate its intracellular region [ 203].
This modelling study shows that a decision to adopt a Telephone Counselling program over existing practice (Real Control) is likely to be cost-effective.
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