22 This modelling study assumed that patients below the treatment threshold derived no cardiovascular risk reduction from treatment whereas those above the treatment threshold did.
These results, although in line with empirical observations, contrast those of previous modelling studies that assume no PrP gene association with other traits besides scrapie.
This estimate is higher than most previous modelling studies, which assume an AVE of 30% (e.g. [ 20, 22, 27]).
It may also lead to more false-positive results as has been pointed out by a modelling study that assumes that test performance does not change during repeat testing [ 13].
In most of the modelling studies, it is assumed that all the horizontal currents in the ionosphere flow within an infinitely thin sheet at some fixed altitude (usually 110 km) above the ground.
In this larger network, CCA1 and LHY show different connections to other genes (such as TOC1) although they are semi-redundant [ 26] and in modelling studies are often assumed to behave identically.
Many modelling studies of scrapie have assumed that outbreak duration would be affected by both flock size and the frequency of PrP genotypes within a flock [20], [23], [27], [28].
Often in population genetic modelling studies, random mating is assumed.
Other modelling studies for heterosexuals have assumed higher increases [ 5, 19], but we found no studies with significant evidence of such high increases [ 7- 11].
These values are consistent with the values predicted in other modelling studies: for example, β (assumed to be the same for female to male and male to female) was estimated at 0.8 (median) with the 95% posterior interval (0.6, 0.99) in [ 6], at 0.6 in [ 9] and 0.4 in [ 7].
