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The dominant contribution of tropical ecosystems to the large land-atmosphere flux during El Niño conditions due to the opposite variation of NPP and Rh has been noted in other modelling studies as well [ 13, 22].

The dominant contribution of tropical ecosystems to the large land-atmosphere flux during El Niño conditions due to the opposite variation of NPP and Rh has been noted in other modelling studies as well [13, 22]. Figure 4 Model results for 1998.

Correspondingly, the potential technical routes are provided and some examples of preliminary modelling studies as the preparation steps for MGI are presented.

One way to address this important topic would be to conduct modelling studies as an integral part of guideline development.

Multiple imputation (MI) provides an effective approach to handle missing covariate data within prognostic modelling studies, as it can properly account for the missing data uncertainty.

For example, whilst the term validation may be semantically debatable [ 13], it is synonymous in prediction modelling studies as referring to evaluating performance, yet, in the studies included in this review, only 43 papers (55%) included the term in the abstract or title (24% in the title alone).

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Decision analytical modelling-based studies, as well as studies employing hypothetical data or summary evidence for costs and effectiveness were considered beyond the scope of this review and were excluded.

However, the normality assumption may not be appropriate for all the parameters of interest when analysing prognostic modelling studies, such as predicted survival probabilities and model performance measures.

Previous modelling studies, such as prior work by the authors with the same simulation model used here (see [ 7] supplementary info), and others [ 17], have found that, as might be expected, school closure is less effective in the case of uniform age-specific attack rates.

In systematic reviews including trial-based and model-based economic evaluations, the CHEC list should be combined with issues relevant to modelling studies such as structural assumptions.

Furthermore, excluding economic evaluations that synthesise secondary data in modelling studies is recognised as a limitation.

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