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Cox proportional hazards modelling stratified by trial centre was used to estimate hazard ratios and confidence intervals.
Multilevel Cox regression modelling, stratified on matched sets, described the association between prosthesis type and time to death, accounting for variation across hospital trusts.
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p value, and hazard ratio were calculated using Cox proportional hazard model stratified on trial.
We also performed exploratory analyses in which we ran multivariable-adjusted models stratified by age (<55 years of age compared to ≥55 years of age).
The probability of VAP occurrence over time was compared between the two study group using a Cox proportional hazard model stratified on trial.
In both groups pooled together, we used a Cox proportional hazard model stratified on trial to identify factors associated with the occurrence of VAP.
A Cox regression model, stratified by age, was carried out to identify the independent covariates affecting 28-day overall survival (Table 3).
The analysis procedures were conducted separately in time series models stratified by status of temperature sensitivity (i.e. temperature sensitizer vs. temperature non-sensitizer groups).
We additionally fit our final models stratified by survey year.
Village was included in all models a priori, whilst in models stratified by age, sex was included a priori and age (in years) was included a priori in models stratified by sex.
The predictors of gametocyte appearance during the follow-up in patients without gametocytaemia on admission were assessed by a Cox regression model stratified by site.
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