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On the basis of the analysis of the active site residues and molecular modelling of substrates in the active site of representative AT domains, we have identified a crucial residue that is likely to play a major role in discriminating between malonate and methylmalonate during selection of extender groups by this domain.
Figure 5 Schematic model of substrate recognition site of PahZ1KP-2.
e Structural model of substrate corresponding to part (d).
On the basis of the present findings, we propose the following model of substrate binding of PahZ1KP-2 (Figure 5).
However, no molecular models of substrate binding and catalysis are hitherto available for this enzyme.
This paper presents an integrated model of substrate clogging in a vertical flow constructed wetland (VFCW).
A mathematical model of substrate material selection is proposed to obtain the high PIDE with large incident angle.
Based on our findings, we propose metabolic systems for each substrate and molecular models of substrate recognition system in C. cellulovorans.
Electrical characterizations have been performed on dedicated test structures in order to extract electrical models of substrate coupling phenomena when RF signals are propagated in TSV.
We also showed for the first time that the Luong model of substrate (molybdate) inhibition kinetics of Mo-blue production was better than the Haldane model.
These data were used to generate a model of substrate translocation for P-gp whereby the binding of nucleotide causes re-orientation of the drug-binding site.
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