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Modelling of fibrosis progression or regression and prognostic performances were similar for FT and liver biopsy whatever the cause of the liver disease; 4 6 18–24 both methods had the same limitations for discriminating between intermediate stages of fibrosis.
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Fig. 4 Overall significant metabolites from models of fibrosis, necroinflammation and steatosis.
This is consistent with the critical importance of this cytokine in diverse models of fibrosis in various tissues.
In the current review, we contrast different in vitro models based on increasing dimensionality (2D, 2.5D and 3D), with added focus on contemporary 3D pulmonary models of fibrosis.
Here, we exploit recent advances in stem cell derived human intestinal organoids (HIOs) as a new human model of fibrosis in CD.
Dramatic increases in HA and versican have been demonstrated, in animal models of fibrosis and inflammation, in both lung tissue and bronchoalveolar lavage fluid.
Halofuginone is an inhibitor of collagen type I synthesis in cells derived from various tissues and species and in animal models of fibrosis in which excess collagen is the hallmark of the disease.
Similar results were found using a model of fibrosis associated with chronically inhaled endotoxin [31].
We chose a dose greater than previously demonstrated to be efficacious in murine models of fibrosis [22].
EMT has been observed in several experimental models of fibrosis where it has been shown to account for up to 20% of the interstitial fibroblasts [9] [12].
In this context it is remarkable that diminished PPAP-γ expression or function is a recurring theme in human fibrotic conditions and animal models of fibrosis.
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