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Series of substituted 4,6-diamino-1,3,5-triazine-2-carbohydrazides and -carboxamides have been synthesised, based on molecular modelling of candidate structures related to the previously reported Rad6B-inhibitory diamino-triazinylmethyl benzoate anticancer agents TZ8 and TZ9.
By comparing a limited set of prokaryotic proteome sequences amino acid frequencies canonically discriminating psychropilic, mesophilic and thermophilic species were determined after modelling of candidate genes on existing three-dimensional structures [ 43].
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Ms. Scozzafava fit the model of candidate advocated by Republican leaders like Mr. Steele and Senator John Cornyn of Texas: one whose views might not be in keeping with much of the national party but are more reflective of the district.
A definite indication for a putative role of IxACs as anticomplement therapy must await tests in animal models of candidate diseases.
Additionally, phenotypic characteristics reported in animal models of candidate genes (i.e., maternal behavior, an abnormality in or lack of grooming, nursing, or retrieval of pups).
With Phase II HIV vaccine trials planned among MSM in India [ 9], we explored mental models of candidate HIV vaccines and clinical trials.
We explored mental models of candidate HIV vaccines and clinical trials that may impact on the feasibility and ethics of biomedical HIV prevention trials among men who have sex with men (MSM) in India.
Politics, Smith told me, is still working off the Hillary Clinton/Jeb Bush model of candidates unwilling to take risks.
Structural modelling of the candidate client RIPK2 suggests an impact of the mutation on a proposed Hsp90 binding domain.
Intuitively, we consider models consisting of candidate regulators supported by considerable external evidence to be frontrunners.
We then used these measures to model thestability of candidate housekeeping genes using a randomised test of variance.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com