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The results were established by modelling in vitro time-kill data with pharmacokinetic properties of marbofloxacin.
The aim here was to study whether hESC-derived neuronal cells and networks could be cultured in native CSF for further, more valid, disease (e.g. MS, subarachnoidal haemorrhages, traumatic brain injuries) modelling in vitro.
The scientsts who had applied to HFEA moved on to work on the new iPS technologies for disease modelling in vitro.
Research on the role of the CID in function to test this hypothesis can be carried out using a myriad of experimental and computational techniques such as molecular modelling, in vitro and in silico binding studies coupled to site-directed mutagenesis, enzymatic assays, and crystallization of the holo-proteins.
While initial hopes raised by hESCs were directed towards their potential use in replacement therapies, the focus of research has now shifted to the development of pluripotent cell-based models for drug research, toxicological test systems and disease modelling in vitro.
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LMNA-related DCM was modeled in-vitro using patient-specific iPSC-CMs.
An interesting feature of muscle fiber cellularization is that it can be modelled in vitro using skeletal muscle myotubes [20].
It is difficult to model (in vitro) partially healed fractures or the contribution of soft tissues to stability accurately.
By such integration, scientists can model In vitro assays using In silico descriptor packages while making benefit of multi-learning features and automatics applicability domain estimation.
These effects can be seen in vivo as well as modeled in vitro.
Chronic, low dose, in vivo effects of any reagent are often appropriately modeled in vitro, by proportionately higher doses of that same reagent, over more acute time frames.
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