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The "Unitary Concept" was mainly based on the data of tuberculin surveillance during the pre-antibiotic era as well as the data obtained from experimental modelling in animals.
Depending on how much emphasis is placed on the different aspects of AD modelling in animals (symbolized by the 'M' in Figure 4), the balance of 'achievement' will vary.
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Migraine with aura is a complex neurological disorder modeled in animals by cortical spreading depression.
This delivery system demonstrated remarkable antitumor efficacy in various orthotopic human cancer models in animals.
Current assessment of orthotopic tumor models in animals utilizes survival as the primary therapeutic end point.
Modeling schizophrenia in animals represents a formidable challenge because the most characteristic symptoms of this disorder, auditory hallucinations and delusional beliefs, cannot be directly modeled in animals.
These microstructural alterations can be modeled in animals and can be measured using stereological methods applied to imaging datasets.
In particular, brain organoids can be generated that can be used to model various neurodevelopmental or neurodegenerative disorders that have been difficult or impossible to model in animals.
The ability to develop experimental non-union models in animals will assist in the investigation of this problem and are likely to lead to novel treatments.
Though not capable of consciousness or other higher cognitive functions, the minibrains allow scientists to study aspects of the developing human brain that are difficult to model in animals.
In our current study we have carried out TGs expression studies in the SF cells and we would be exploring this further using wound healing models in animals.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com