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The scientists emphasise the technique's use in modelling diseases and creating therapies.
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Such constructs provide a platform for understanding neuronal coding and learning, an arena for modelling disease, and ultimately a step towards creating intelligent neuroprostheses.
In the research section of this collection, Jan-Luuk Hillebrands and colleagues (Poosti et al., 2015) provide an example of how ex vivo tissue systems are central to modelling disease and testing drugs.
In transgenic mice, the development of conditional strategies to control gene expression in a spatial and temporal manner has been crucial for modelling human diseases and deciphering tissue-specific gene functions [ 1].
For both human and plant diseases, a challenge in modelling disease spread in dynamic networks is the use of metrics that can account for dynamic properties (Natale et al. 2011), given that most network metrics are based on static networks (Bajardi et al. 2011 b ; Nöremark et al. 2011; Klemm et al. 2012).
Keller and colleagues reviewed important factors predisposing patients to recurrence of depressive symptoms and highlighted several risk factors that should be considered when modelling disease evolution [ 7].
A broader outcome measure, such as dependency, could be considered as an alternative for modelling disease progression.
A novel source of cardiomyocytes for modelling disease is human pluripotent stem cells (hPSC).
Mice are most commonly used for modelling disease because of the relative ease of precisely manipulating the genome by gene targeted homologous recombination [ 14].
This review is focused on summarising the PKPD information available in paediatric infectious diseases and immunology, the modelling approaches taken, and identifying potential avenues for future PKPD research.
Reviewer #2: This manuscript reports a modelling analysis estimating the effectiveness of airline screening for infectious diseases and the impact of disease-specific characteristics on this efficacy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com