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However, the modelling complexities are formidable and involve numerous steps.
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In the case of neurotrophic factors, an additional level of modelling complexity is added by the fact that they are secreted, and will affect multiple cells, including non-transduced ones.
Within this context, three modelling strategies of different complexity are proposed: equivalent frame model, rigid macro-block model and finite element model.
Different modelling approaches of varying complexity are available in the open literature.
In the second part of this article, three dual-satellite modelling approaches with low complexity are analysed on a large set of receive scenarios: a first-order Markov model for correlated satellites (Lutz model), a semi-Markov approach assuming a lognormal SDPDF fit, and a semi-Markov approach assuming a piecewise exponential SDPDF fit.
Another advantage is that model construction and the need for additional complexity are driven by particular questions or modelling aims, ensuring that the resulting model is 'fit for purpose'.
Strategies to reduce complexity are manifold: examples are system modelling, contradictory analysis or prospective imagination.
Uncertainty and complexity are the main limitations of this modelling approach.
The main implication of this increased complexity is the need of modelling the whole day and using, at this aim, more complex and rigorous travel demand modelling approaches.
Complexity is considered a major drawback of the modelling approach for quantifying the magnitude of overdiagnosis.
According to Mr Derman, rivals copied innovations within months, so the arms race in modelling tended to lead to complexity, because you could charge more for it and because complexity is harder to reverse-engineer.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com