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Primary pneumococcal pneumonia was modeled as previously reported (Arredouani et al., 2004).
Protein 3D structural models were built by homology modeling as previously described (Duarte-Pereira et al., 2014).
Structure of CRYBA3 as an open conformer was modeled as previously described., CRYBA1 floxed homozygous mice (Cryba1fl/fl) were generated as described previously.
A JND model was applied as a human visual model as previously mentioned in [17].
We used the standard ultrasound technique for measuring ONSD on our models as previously described [16, 18].
[11C]Raclopride binding was quantified using BPND values derived from a simplified reference tissue model as previously described (Ikoma et al. 2009).
The increased availability of statistics for model parameters as a result of substructural observation will elucidate the strengths and weaknesses of the model as previously proposed.
The simulations used are based on the known experimental and spin Hamiltonian parameters and on a structural model as previously employed for similar systems.
To account for these experimental results the acceleration of physical aging has been rationalized in the framework of the diffusion of free volume holes model as previously proposed.
The results were analysed assuming a one-to-one binding model as previously described [27].
We used non-informative priors in Bayesian models, as previously published [22].
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