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The results obtained provide a clear indication of the strengths and weaknesses of either modelling approach, as well as of the suitability of the local thermal equilibrium assumption in general.
To estimate the model parameters, population analysis was performed using the non-linear mixed effects modelling approach as commonly done, where data from all patients are analysed simultaneously (described in the Supplementary Material 4; Sheiner, 1984).
This contribution proposes a multilevel modelling approach as a tool for the decision-making task in the early design stages of reactive distillation processes.
We recommend this type of simple modelling approach as the first step in determining whether a proposed offsets scheme is worth investigating further.
Simulation results obtained demonstrate the feasibility of the present modelling approach as a useful numerical tool to help potential improvement of industrial scale Pachuca tank design and/or operation.
Using a similar modelling approach as above, we test the role of arousal in two ways.
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A major recommendation is that biosphere assessments need to justify the degree of complexity in modelling approaches as well as simplifying and conservative assumptions.
These models have considerable advantages over traditional modelling approaches as they remove the need to manually determine slope length and angle and because they can also determine both erosion and deposition.
In fact, one purpose of this study was to compare the performance of these modelling approaches as no study was found contrasting their prediction capability in the literature.
As mentioned previously, the cochlea is usually uncoiled in most modelling approaches, as coiling was reported to have a negligible effect on cochlear micromechanics.
To exploit these aspects, in this paper we introduce a hybrid modelling pipeline combining available genetic knockout data with logical, ODE-based and stochastic modelling approaches as outlined in Fig. 1 a- d.
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