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The degree to which all aspects of JBTS have or even can be modelled in mouse is difficult to assess.
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Indeed, pathological activation of Erb B2 can increase demyelination (Guertin et al., 2005; Tapinos et al., 2006) and inhibiting Erb B2 can improve some features of DPN modelled in diabetic mice (McGuire et al., 2009).
In the present study, we characterized a novel neuropathy model in mice and tested the hypothesis that myelin outfoldings and tomacula result from a local loss of myelin growth control, modelled by abnormal PtdIns 3,4,5 P3 stimulation in Schwann cells.
Studies of Brugada syndrome, modelled in Scn5a mutant mice, have been instrumental in understanding channelopathies [ 13].
As noted for dystrophin-deficient zebrafish above (Berger et al., 2010), severe human MDs such as UCMD or DMD are more closely modelled in zebrafish than in mice.
Ben Sanchez in Mouse.
The term "model" implies that particular phenomena can be represented (i.e., modelled) in multiple ways.
"Its time for an independent inquiry, potentially modelled in the Hillsborough panel, to open up everything.
That's the economy that's effectively modelled in Bogdanov's Red Star.
Is this boutique, sofa-clad destination modelled in Vancouver the bank branch of the future?
The adhesive layer is modelled in two ways.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com