Only one form of scFv huHMFG1-Ala71 was modelled because all the scFv structures with an Ala at VH-71 exhibit the same conformation as in PDB entry 1EO8 (Fleury et al, 2000).
Interactions between confounding variables were not modelled because of the small sample size.
On the other hand, the SNP effects on protein functions were inferred by modelled structures because the molecular modelling method has been found useful for estimating the effects of the substitution of amino acid residues on protein function.
For the uppermost 20 mm between the h4 and h5 levels, the cortical layer was not modelled because of its thinness and its resulting properties being similar to cancellous bone.
Furthermore, the average effects of these heterogeneities on transmission dynamics are unlikely to vary significantly over the period that is modelled because of limited effects of infection saturation during this period of declining HIV-2 prevalence.
We used a study in which the course of patients who had not responded to antiviral therapy was modelled because in our analysis all HCWs with CHC had failed a first antiviral treatment for acute hepatitis C. In the study of San Miguel et al, patients received an additional course of standard IFN and ribavirin combination for 12 months and the course of the disease was simulated until death.
Using latent variables has some effect on the modelled (co variance structures; because the latent variable model uses less parameters than the full (co variance matrix, the (co variance structure is somewhat restricted, similar to using only the main principal components in a principal component analysis or frequentist factor analytic model, e.g., [ 34].
It was not possible to obtain data on trans fats levels for either the modelled scenarios or the baseline diets, because trans fats are not recorded in the FFS, so throughout, we have assumed that trans fat intake would remain constant at 1.6 g/day, the average level of consumption in the UK in 2008/09.
Indeed, language should be viewed as being all of these things, because language as modelled in the instantiation cline operates at all of these strata simultaneously (Halliday 2002: 19; Martin 2009: 559).
