With careful and explicit cross-checking between models as their structure evolves and the spatial complexity increases, our understanding of the model assumptions can similarly evolve and reveal otherwise unnoticed dynamics in the modelled system.
Moreover, a close fit between modelled estimates and observations does not give proof of the validity of the model assumptions – merely its predictive ability.
The feasibility of adding a modelled economic evaluation (to broaden the target population; lengthen the time horizon beyond that of the trial; and estimate cost offsets) will also be carefully assessed, having regard to trial results and the strength of evidence in the literature to underpin key modelling assumptions.
IEDs with different electroclinical characteristics have been modelled as separate effects, reflecting the modelling assumption of distinct generators [Jacobs et al., 2009; Vulliemoz et al., 2010].
AV participated in the design of the study, carried out the policy document search and selection process, conducted the interviews, analysed the documents, modelled the assumptions and drafted the manuscript.
This analysis assumes underlying Gaussian distributions of any modelled modes an assumption that seems reasonable as most genetic and behavioural human variation is typically normally distributed.
These occupancy series are modelled based on assumptions about their state space, loss function, and predictor action.
We simulated four different landscapes, three with different species but the same rotation length and one using the same species with two different rotation lengths, to evaluate interactions between modelled scenarios and assumptions about parameter variability.
The translation of these skill requirements into workforce or service structures is then modelled, incorporating various assumptions about the occupation group(s) best suited to deliver the identified competencies.
The lifetime costs of ART must therefore be modelled based on assumptions about not just the cost of first line therapy and the number of new infections, but also the effects of ART on longevity, the likelihood of needing to switch to second line drugs, and the other health care costs that are incurred such as management of opportunistic infections.
