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The N-terminal and C-terminal regions were modelled as reported in Methods and resulted made of six very short helices inserted with seven short β-strands and of five short helices inserted with five short β-strands, respectively.
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Model parameters were as reported in Brette and Gerstner (2005) and synapses were modelled as input currents.
Fig. 2 Comparison of the modelled rates of degradation using Eq. (7) and the observed rates of degradation as reported in the literature (as indicated).
However, residual electron density from severely disordered guest and solvent molecules, which is readily visible but cannot be reasonably modelled, as per previously reported guidelines, will inflate the R 1 and wR 2 refinement statistics, and leads to slightly larger absolute configuration parameters.
Cost differences between the treatment strategies were also modelled and are reported in the Results section.
As we were considering a relatively short time-span within a year, it was not necessary to fit a smoothed term of week; rather we modelled reporting rate as a function of garden size, week (and its square to account for any non-linearity) and a two-level dummy variable, year, with weeks in 2005/06 having year = 0 and those in 2007 year = 1.
The channels are modelled using the pathloss model reported in [11].
AGC was not modelled as it represented 0.1%% of reports by the NHLS from 2010 to 2014.
Because we modelled log(BMI), the modelled effect of each allele is reported as a percentage change (increase or decrease) in BMI.
Alternatives to these scenarios have also been modelled but are not reported in detail here.
In much of the theoretical work reported, pathloss between two points is modelled as a known function of their separation, but in real systems this is an average, not a true reflection of the actual pathloss.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com