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The recommended doses, along with the pharmacokinetic parameters, used for modeling were obtained from the package inserts for amantadine [14], oseltamivir [15], and ribavirin [16], and the references therein.

Longitudinal data with annual standardized measures such as rates and percentages for this change modeling were obtained from a number of national data programs for all 50 states.

By testing different combinations of the parameters included in the uncertainty analysis, the maximum and minimum psat and Δ Hvap (one component modeling) and Forg,model (two component modeling) were obtained.

Similar results for the unadjusted and adjusted conditional logistic regression modeling were obtained when examining renal cell carcinomas only (P-trend = 0.67 for the multivariate-adjusted model) and when limiting the sample to cases diagnosed more than 2 years after blood draw and their matched controls (P-trend = 0.95 for the multivariate-adjusted model).

Plasma vismodegib concentrations for the PopPK modeling were obtained from phase I studies SHH3925g (NCT00607724) and SHH4610g (NCT00968981) (total and unbound concentration), the phase II study SHH4476g (NCT00833417) (total concentration), and the healthy volunteer (HV) studies SHH4433g (total and unbound concentration) and SHH4683g (NCT00991718) (total concentration).

Similar(55)

The survival data for modeling was obtained from the Breast International Group BIGG) 1-98 trial [8].

Significant models were obtained.

Seven LDA-based QSAR models were obtained.

Two QSAR regression models were obtained from INCHEMICOTOX.

Training datasets for both models were obtained from JRC QSAR Models Database.

At these optimal conditions, kinetics and isotherm models were obtained.

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