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From the analysis of structures of these complexes and modeling we identified the key amino acids present in the entire interacting surfaces among these proteins that play important physiological role in the regulation of cell differentiation and bone metabolism.
The developmental trajectories were characterized with teachers' ratings of CU traits and CP from ages 7 to 12. Using general growth mixture modeling, we identified four trajectories of CU traits (stable high, increasing, decreasing, and stable low) and two trajectories of CP (high and low).
Using structural equation modeling we identified a gene-environment (G×E) interaction using observer-report but not self-report measures of environmental stress exposure during adolescence: 5HTTLPR genotype and observer-reports of home and neighborhood quality (HNQ) during adolescence interacted to predict self-esteem levels in young adulthood (p<.004).
Through polygenic modeling we identified total cholesterol and T2D as key traits and proceeded with an mt-PheWAS to determine if the use of polygenic modeling for phenotype prioritization is robust.
Using molecular modeling, we identified differences in the water-mediated network at this position between bromodomains.
By homology modeling, we identified two hydrophobic residues in the substrate-binding groove that contribute to substrate specificity.
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Following the "pattern-oriented" modeling strategy, we identified nine observed patterns that characterize the real system's dynamics.
Using a combined regression and modeling approach, we identified six groups of cells that were highly selective for the best prey-like stimuli.
Based on empirical data from process modeling practice, we identify and discuss different labeling styles and their use in process modeling praxis.
By comparing the modeling results with experiments, we identified the key characteristics of the butterfly scales that were relevant to chemical sensing applications.
Through structural modeling and site-directed mutagenesis, we identified several key amino acids of these UGTs that may play important roles in determining their activities and substrate regio-specificities.
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