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Descriptive data and data regarding the microbiological outcome variables were analyzed using IBM SPSS Statistics 22 Version 22.0 (IBM Corp. Armonk, NY: IBM Corp .. Multilevel models were analyzed using MLwiN version 2.12 (Centre for Multilevel Modeling, University of Bristol, Bristol, UK).
Centre for Multilevel Modeling, University of Bristol) was used for fitting the model.
MLwiN 2.30 (Centre for Multilevel Modeling, University of Bristol, Bristol, UK) was used for multilevel regression analyses (Technical Appendix).
Subsequently, we used random coefficients analysis (MLwIN, version 2.23, Centre for Multilevel Modeling, University of Bristol) to evaluate differences in overall effects between the groups for the 12 week intervention phase and the follow-up phase.
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