Additionally, BNs have been used for modeling the cell cycle [ 12- 15]; cell proliferation [ 16- 18]; apoptosis [ 19]; and cancer [ 20].
In contrast, in the MIN-O model, the proliferation of the 'premalignant' growth begins upon transplantation, and therefore the time to malignant transformation is easily measurable.
In this model the proliferation term combines the cell division and mortality of cells, which is assumed to depend on the activity p of P-gp only during the treatment.
In a mouse fibrosarcoma model, the proliferation rate of highly metastatic potential cell lines was higher than that of non-metastatic or intermediate potential cell lines in stiffer condition [ 30].
Third, in the viral model the proliferation of the NK cells in the absence of IL-15 (or IFN-α/β) was maintained by the activating NK-cell receptor Ly49H, which is directly targeted by a single, highly stimulatory viral glycoprotein m157, and by IL-12 43, 43.
To describe the effect of TDM-1 on platelets, Bender et al. [ 55] modelled the proliferation compartment as composed of one drug sensitive and one drug non-sensitive lineage, in order to capture the downward drift in platelet nadir, seen in some patients.
This model is used to inform a tissue-level model of the proliferation and death of prostate epithelial cells.
Characterising and modelling the attachment, migration and proliferation of cells on materials used for tissue engineering provides valuable insight into their potential applications as well as a means of objective comparison.
In the postwar era, with the triumph of the biomedical model and the proliferation of drugs and techniques that did successfully extend life, many doctors would just as soon have forgotten about the placebo effect altogether.
We present a mathematical model for the proliferation and differentiation of human mesenchymal stem cells grown inside artificial porous scaffolds under different oxygen concentrations.
