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Modeling the origin of variation amounts to specifying a space of possible: how many mutations can arise per generation and what is the range of their fitness effects?
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ClonalFrame does not model the origin of recombination events [ 58].
In this paper, we extend our previous work (Zheng et al. 2014) to model the ancestral origins along a pair of X chromosomes in a finite mapping population.
"Unmanned" was going to have to change to fit STX's model — the origin story that explained to investors how the company would reinvent the Hollywood formula.
According to this model, the origin, and adjacent DNA sequences whose replication depend on it, define an independent unit of replication, or replicon.
In our model the origin of adhesion patch growth is that the initial tension-dependent mean membrane separation in the GUV-GUV or GUV-SBL contact zone (Fig. 1B) normally exceeds the reach of cognate SNAREs (∼8 nm [33]).
In this tumor progression model, the origin of the first transformed cell is irrelevant but focuses on adaptive biological processes induced in tumor cells through genetic or mitochondrial mutations [44].
For each model, students needed to evaluate whether and in what part of the model the origin of variation was represented (Supplemental Figure S4).
In our simplest model, the origin of this projection grid shifts with the soma of the neuron making an axonal arbor (black dot in Fig. 3 a ).
Differing from above models, a crystallization model owes the origin of threshold switching to the field induced nucleation of conductive cylindrical crystallites [88].
We assess the impact of orbit modeling on the origin offsets between GRACE kinematic and reduced-dynamic orbits.
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