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The intelligent modeling system defines classes with attributes to represent various aspects of physical entities.
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These genetic results suggest that p21 acts through the cyclin D1 cdk4 complex to support tumor growth, and establish the utility of using a somatic cell modeling system for defining the contribution proteins make to tumor development.
Numerically, we find that model systems defined by Eqns. (1) and (4), have at most one stable equilibrium.
The budding yeast, Saccharomyces cerevisiae, is a powerful model system for defining fundamental mechanisms of many important cellular processes, including those with direct relevance to human disease.
The apoAI gene provides a model system to define the mechanism(s) governing intestinal cell specific gene regulation and the role of nuclear hormone receptors in the establishment and regulation of enterocytic gene transcription.
The nematode Caenorhabditis elegans is a powerful model system for defining genetic and pharmacological interventions promoting longevity and healthy aging, often by mechanisms that appear conserved across phyla [13], [23], [24].
We used a human cardiomyocyte tissue culture model system to define these events.
The naturally occurring diversity in the neuropathogenicity among strains of WNV provides an excellent model system to define virulence determinants of emergent strains.
Therefore, comparative studies between HDFs and HKCs would provide a unique model system for defining the signaling pathway by which TGFβ3 blocks growth factor-stimulated cell migration – the anti-motility signaling mechanism by TGFβ3.
In order to gain experimental evidence of the pathological significance of Ataxin-3 protein cleavage in vivo, we used the fruit fly model system to define potential cleavage of the Ataxin-3 protein in the nervous system in vivo, and the consequences of preventing that cleavage pattern.
Previous studies established the relative preferences of these peptides for membrane model systems of defined lipid compositions.
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