Expression of MAPKs has previously been described at elevated levels in the RA synovium, and data from different animal models suggest important yet distinct roles of the three MAPKs in destructive arthritis.
While simple scaling laws, in no way, can be claimed as reliable predictive models, they suggest important features that can be used to guide further research.
These models suggest two important quantities that can be calculated from movement data: turning angles and directional biases.
Animal models suggest an important role for cytokines in experimental pancreatic carcinogenesis (Watanapa and Williamson, 1993).
Animal models suggest an important pathogenetic role of FGF23 for left ventricular hypertrophy.
The existence of embryonic macrophage-like cells has been reported in all animal models and its conservation suggests important roles during development.
Data from animal models suggest that an important fraction of DTCs might remain in a 'dormant' state and never develop into overt metastases.
Cryo-EM models suggest that the important actin regulatory protein coronin binds along this groove and makes extensive contacts with the upper edge shown in red in Figure 7B (Galkin et al. 2008), overlapping with the residues mutated by act1 -122 of cluster 6.
The apparent difference between the mouse gene knockout and zebrafish models suggests that important aspects of the Prion protein biology may be revealed in the zebrafish model, using morpholino (MO) mediated translation blocking [10].
Increased expression of sLepR is associated with lower body weight in murine models, suggesting the important role of sLepR in leptin regulation [ 12].
