Computational docking and modeling studies focusing on the structure of human PXR identified key amino acids within the ligand-binding domain that permit BPA to interact with the receptor.
The first "wave" of disease modeling studies focused on generating patient-specific human neurons and confirming previously described pathologies (Dimos et al, 2008; Ebert et al, 2009; Marchetto et al, 2010; Brennand et al, 2011; Seibler et al, 2011; Bilican et al, 2012; Israel et al, 2012).
Out of a heterogeneous dataset of cPLA2α inhibitors, examples shown in Figure 1, this molecular modeling study focused on three chemical classes that are composed of an aryl-alkyl-/alkyl- oxy) side charyl-alkyl-/alkyl- oxyl moiety, aryl-alkyl-/alkyl- oxywo to three aryl-alkyl-/alkyl- oxy
Modeling studies focusing on a specific component of the Earth system have provided valuable insight into processes controlling their behavior and the direct impact of climate change.
A recent mouse model study focused on the metabolic consequences of an NSML-associated mutation in SHP2, and found impaired adipogenesis and a better metabolic profile, which result in reduced body mass index (BMI) (Tajan et al., 2014).
Using the GK rat model, a study focusing on granule motion before fusion showed a reduction in fusion events [ 17].
For the TGR area, previous water quality modeling studies have been focused on the simulation of 1D and 2D hydraulic flow in the mainstream of Yangtze River (Huang 2006), analysis of the natural assimilative capacity and water environmental capacity, definition and calculation of pollution mixing zones (Jiang et al. 2005), and some others (Zhao et al. 2011).
We present a comprehensive modeling and numerical study focusing on the energy quasi-static crushing behavior and energy absorption characteristics of hollow tube microlattice structures.
Typically, modeling studies of influenza spread are focused on predicting international or national spread between major hubs on the global air-transportation network (8, 9, 13 ), which is certainly important.
Anthropophilic mosquitoes, such as Ae. aegypti, are believed to serve as significant bridge vectors to humans [35], and thus act as a suitable model vector for our study focusing on the effect of mosquito feeding on WNV transmission to mammals.
