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Around this time, a rapid transition from 2D to 3D modeling studies was underway.
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All modeling studies were performed using the SYBYL-X 2.0 molecular modeling package (Tripos Inc., St . Louis USA) running on a windows 7, 32 bits workstation.
The modeling studies were conducted using a 3D finite element model of the uncoiled cochlea and consisted of simulation of the RW membrane vibration amplitude in the frequency range 0.4 10 kHz in both the pre-stapedotomy and post-stapedotomy states.
Molecular modeling studies were carried out to ascertain the binding of the model compound to the active site of β-tubulin.
Results from related modeling studies are also presented, showcasing the intriguing potential of the system with modeled cycle electric efficiencies up to 62%.
They claim that the main limitation of modeling studies is their lack of transparency, and that prior publication of the model in peer reviewed statistics literature is a positive indicator of the model's validity.
Molecular modeling studies are also described.
Molecular modeling studies were accomplished using Glide docking tool.
Molecular modeling studies were done to verify the biological activity.
Molecular modeling studies were performed to explain biological results.
Molecular modeling studies were carried out to optimize the pharmacophore.
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