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A crystal structure of an Fc fragment with the mutations S239D/A330L/I332E was solved and modeling studies suggested that additional hydrogen bonds, hydrophobic contacts, and/or electrostatic interactions resulted in enhanced binding to FcγRIIIa (Oganesyan et al., 2008).
The crystal structure of the mutated Fc was solved and modeling studies suggested that conformational changes at P329 would not be favorable for formation of the "proline sandwich" and changes at D270 could negatively impact C1q interactions.
Previous homology modeling studies suggested that YfiB contains a Pal-like PG-binding site (Parsons et al., 2006), and the mutation of two residues at this site, D102 and G105, reduces the ability for biofilm formation and surface attachment (Malone et al., 2012).
Thus, modeling studies suggested that intravitreal administration of the current clinical doses of ranibizumab and bevacizumab would result in effective VEGF-A inhibition of relatively similar duration, while VEGF Trap might be as efficacious as ranibizumab, but with less frequent dosing.
Kinetic analysis and molecular modeling studies suggested that 5c could bind simultaneously to the catalytic active site (CAS) and peripheral anionic site (PAS) of AChE.
Further, molecular modeling studies suggested these mutations might increase the protein folding efficiency by improving the packing of a hydrophobic core in the α1β1 domain of DR1.
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However, such research is lacking when it comes to tornadoes, with computer modeling studies suggesting that conditions may become more favorable for tornadoes as the climate warms, but perhaps not by very much.
Indeed, over many years, modeling studies suggest the reserve could even encourage the evolution of "lazier" but healthier fish populations, says fish geneticist Jon Mee, a former colleague of Pauly's who is now a postdoctoral fellow at the University of Calgary in Canada.
Moreover, modeling studies suggest that antiviral-resistant strains may spread rapidly and markedly affect pandemic outcomes (9 ).
The heritability of Breakfast Skipping has been assessed by twin modeling studies suggesting that additive genetic effects explain 0.41 of the variance in girls and 0.66 in boys [Keski-Rahkonen et al., 2004].
A recent computer modeling study suggests that bullets would bounce off a carbon-nanotube fabric just six layers thick.
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