Molecular modeling studies suggest a structural basis for the agonist activity of these compounds.
Mutagenesis and modeling studies suggest that incorporation of the analogs into EGF8 of Notch1 markedly reduces the ability of Delta ligands to bind and activate Notch1.
Thermal modeling studies suggest that blueschists will generally undergo heating and be converted to greenschist assemblages if exposure at Earth's surface does not occur within 100 million to 200 million years after high-pressure metamorphism.
However, laboratory and modeling studies suggest that dispersal trajectories might also be shaped by oriented swimming [11 15].
Molecular modeling studies suggest that 5-thiomethylthiopheneamidine inhibits uPA by binding at the S1 pocket of the active site.
Molecular modeling studies suggest that the nitrogen atom in the isoquinoline ring plays a key role in ligand receptor interactions.
Molecular modeling studies suggest that (1H-pyridin-4-ylidene)amines may bind to the ubiquinol oxidation Qo site of cytochrome bc1.
Computer modeling studies suggest that 5HT increased INa mainly by decreasing the transition rate (kOI1) from an open state to Ifast.
Molecular modeling studies suggest that both of 2-alkyl quinolones and 1,6-naphthyridine-4,5-diones 1,6-naphthyridine-4,5-diones 1,6-naphthyridine-4,5-diones 1,6-naphthyridine-4,5-diones
Recent field and modeling studies suggest that tectonic forcing and associated increases in erosion rates may either promote or hinder soil chemical weathering.
Molecular modeling studies suggest that AAV2 contributes to surface loops at the icosahedral threefold axis of symmetry, while AAV1 and 9 contribute to two- and fivefold symmetry interactions, respectively.
