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This hypothesis has generated numerous modeling studies demonstrating that the standing level of genetic variation in traits can be explained by the demographic history of a species not linked to fitness of an individual (Wolf et al., 2000; Barton and Turelli, 2004; Hufford et al., 2012; Pyhajarvi et al., 2013).
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On the other hand, modeling studies demonstrate that there is most likely substantial current dispersion under the electrodes, especially at the cerebrospinal fluid level, where the conductance is particularly high [34], [53].
Neural network modeling studies demonstrate that scale-invariant contour grouping is indeed possible in such a hierarchical network (Korjoukov & Roelfsema, manuscript in preparation).
The molecular modeling studies demonstrated that compounds matched the pharmacophore well and had good predicted physicochemical properties and estimated IC50 values.
Modeling studies demonstrate that the CCR5 antagonists bind in a similar pocket of the CCR5 receptor within the transmembrane region (Westby et al. 2005b).
We review evidence from clinical data sets and mouse model studies demonstrating enhanced inflammation and altered tumor microenvironment (TME) upon TS inactivation.
While there are some cell model studies demonstrating activation of IGF-IR by overexpression of receptor or intracellular tyrosine kinases (Kozma and Weber, 1990), activation of IGF-IR requires binding to ligand in most physiologic settings.
Our results are consistent with findings derived from animal model studies demonstrating that the use of a SRL dosage similar to that prescribed in KT was associated with regression of pressure-induced cardiac hypertrophy by means of antiproliferative mechanisms [ 3- 5].
A molecular modeling study demonstrated that EGCG exerts its inhibitory effect on DNMT1 function by blocking entry of the key nucleotide cytosine into its active site by hydrogen bonds and, thus, prevents DNA methylation (Fang et al. 2003).
Recent numerical modelling studies demonstrated how pre-existing (geologically older) fault geometries within a rock volume, strongly control both the distribution of strain and fluid flow patterns during extensional fault reactivation.
Previous mouse model studies demonstrated immunization with r-GV expressing selected exogenous sequences elicited a prolonged immune response.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com