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The molecular modeling studies demonstrated that compounds matched the pharmacophore well and had good predicted physicochemical properties and estimated IC50 values.
Prior modeling studies demonstrated the need for sufficient supplemental immunization activities (SIAs) with OPV prior to globally-coordinated OPV cessation to prevent the creation of circulating vaccine-derived poliovirus (cVDPV) outbreaks after OPV cessation [ 2– 6].
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On the other hand, modeling studies demonstrate that there is most likely substantial current dispersion under the electrodes, especially at the cerebrospinal fluid level, where the conductance is particularly high [34], [53].
Neural network modeling studies demonstrate that scale-invariant contour grouping is indeed possible in such a hierarchical network (Korjoukov & Roelfsema, manuscript in preparation).
Modeling studies demonstrate that the CCR5 antagonists bind in a similar pocket of the CCR5 receptor within the transmembrane region (Westby et al. 2005b).
A molecular modeling study demonstrated that EGCG exerts its inhibitory effect on DNMT1 function by blocking entry of the key nucleotide cytosine into its active site by hydrogen bonds and, thus, prevents DNA methylation (Fang et al. 2003).
Recent numerical modelling studies demonstrated how pre-existing (geologically older) fault geometries within a rock volume, strongly control both the distribution of strain and fluid flow patterns during extensional fault reactivation.
Previous mouse model studies demonstrated immunization with r-GV expressing selected exogenous sequences elicited a prolonged immune response.
Previous DS animal model studies demonstrated that ETS2 had a tumor suppression role in intestinal tumor oncogenesis (41).
Several works in epidemiology and animal model studies demonstrated that compounds which possess antioxidant or anti-inflammatory properties can inhibit carcinogenesis [ 6, 7, 8, 9].
Modelling studies demonstrated that monomeric α-syn can rapidly penetrate the lipid bilayer and incorporate additional monomers to form pore-like structures that fully perforate the lipid bilayer [ 49].
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