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To address whether estimated effects are valid and whether they are strongly influenced by different model specifications during the modeling process, we conducted a series of sensitivity analyses in two areas.
For selecting an adequate model structure, being the most crucial part of the modeling process, we conduct the following forward strategy: We start with the most parsimonious reasonable model and refine it iteratively and directed by biochemical knowledge until subsequent refinement does not significantly improve the model fitting process.
This finding is a direct consequence of the conceptual modeling process we engaged in and a conjecture triggered by the OPM model of the mRNA lifecycle that was confirmed experimentally.
In order to explain the improvement of modeling process, we make a comparison between the improved BN and classic BN (Table 2).
Prior to the modeling process, we recoded the Race variable into Black (20.3%), Hispanic (47.8%), White (27.9%) and Other or Unknown (3.7%).
Through the statistical modeling process we shed light on the variability in the relationship between sequence similarity and function similarity.
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Uncertainty highlighted in the modeling process suggests that we need a better understanding of the historical ecological dynamics of household institutions and land use change in order to better explain relationships between variability in land use intensity and the fire regime.
Thus we simplified the modeling process, yet yielded the variable we were searching for: liver phosphorylation of glucose, i.e., GCK activity.
∥Not reported because no baseline variables retained in model during modeling process.
We then repeated this modeling process, replacing the disease measure with our co-morbidity and then our disability measure.
The Janus Machine is one of the most recent interactive art installations to surface in this realm, and it's a fascinating amalgamation of several 3D modeling processes and techniques we've seen implemented in the past year, many of which originated with the project's creators and were adapted by other artists after the code was released on openFrameworks.
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