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Examples of modeling platforms that can satisfy these criteria, to a greater or lesser extent, are MATLAB (www.mathworks.com), Macsyma (www.symbolics-dks.com/Macsyma-1.htm), Maple (www.maplesoft.com), and Mathematica (www.wolfram.com).
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In this paper we describe Nova, a new Java-based modeling platform that naturally supports the creation of models in the system dynamics, spatial and agent-based modeling paradigms.
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The design of the industrial scale power unit, which is presented at end of the manuscript, was carried out based on the outcomes of a theoretical modelling platform that allowed to investigate and optimize multiple design parameters using energy and exergy analyses.
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We will further discuss existing cell culture and animal models and highlight platforms that have proven to be useful and/or are emerging for studying other hepatotropic (viral) pathogens.
Mathematical models and bioinformatics platforms that perform high level computational integrated pathway analysis may reveal clinical relevant signaling pathways amenable for targeting in individual patient tumors.
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