Since these changes occur spontaneously and seemingly without pathology, mammalian hibernation may be a useful model for investigating physiological aspects of tau protein phosphorylation in vivo.
Additionally, our findings also suggest a high degree of functional conservation between teleostan and mammalian DAergic neurons, thus underscoring the utility of the zebrafish as a model for studying physiological aspects of DA signaling.
Our goal was to develop (see Methods section for details) a modelling tool with which we could simulate the key physiological aspects of the cardiac myocytes.
In addition to structural characterization of model Hirano bodies, limited physiological aspects of these inclusions has also been investigated.
Nevertheless, since F/C is not the ideal model additional studies need to be conducted to better simulate the pathological and physiological aspects of the PSD state.
Marked by genome duplication events, the diversification and adaptive radiation of fish represent an attractive evolutionary model to study ecological, behavioural and physiological aspects of biodiversity [ 2].
Therefore, to investigate cell-ECM interactions and gain an understanding of their role in diseases such as cancer and fibrosis, it is necessary to develop and apply biomimetic model systems that accurately recapitulate the physiological aspects of the ECM and the cell-ECM interface.
However, despite the similarities in molecular, morphological, and physiological aspects, a single animal model will often lack the ability to adequately mimic the complexity of mechanisms underlying a human disease.
Expressed sequence tag (EST) analysis and related applications are useful to elucidate the mechanisms of resistance and virulence and to reveal physiological aspects of this non-model insect, with its poorly understood genetic background.
The UVa/Padova simulator, based on a model by Dalla Man et al., accepted by the Food and Drug Administration to replace animal testing of glucose controllers, and the Cambridge Model, developed by Hovorka et al. for closed-loop glucose control contain physiological aspects and represent the current state-of-the-art in glucose modeling used for model-based glucose control.
