Elucidation and integration of developmental biology into future models of biologic skin substitutes promise to restore complete anatomy and physiology, and further reduce morbidity from cutaneous wounds.
In summary, the molecular target-based DDD paradigm is built on a naïve and misleading model of biologic control and is not heuristically adequate for advancing the mission of modern therapeutics.
Further, the sequence of treatments that we apply has been used previously in economic modelling of biologics in RA. 24 Patients reaching ACR50 on a given therapy remained on that therapy until discontinuation due to adverse events (AEs).
Thus, models of biologics that have focused on short-term disease activity, measured as DAS28 28 or with HAQ 23 24 as the single explicitly modelled variable, offer a limited perspective.
Large-scale organizational frameworks such as the bow tie are necessary starting points for higher-resolution modeling of complex biologic processes.
For such reasons, quantitative modeling of complex biologic processes, such as the eukaryote cell cycle, has been practiced for many decades.
As a final differentiation, this work is not directed at a specific biological issue--although some biological predictions are presented and an investigation of a redundant pathway is included in Additional file 4--rather, it addresses what will be necessary to progress the modeling of complex biologic processes.
As the work reported here involves cell-cycle modeling as an example of modeling complex biologic processes, a brief summary and discussion of recent eukaryote cell-cycle work follows.
This is a first attempt at modeling immunogenicity of biologics, so the model simulations should be used to help understand the immunogenicity mechanisms and impacting factors, rather than making direct predictions.
The present economic model is a cost-minimization analysis assuming similar efficacy at 1 year (ie, the time horizon of the model) for biologic treatments in scope.
