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Game theory modeling of aggressive encounters suggests that threat displays, when they exist, usually provide an honest indication of one's fighting ability [68] [72].
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Now, apart from introducing the specific hazards associated with genetic modifications, GM commercial crops perpetuate the very economic and social model of aggressive exploitation, intensive large-scale cultivations and biodiversity reduction associated with conventional crops cultivated under modern agriculture principles.
Through a business model of aggressive vertical integration, huge poultry companies in the US own and control the birds, the mills that produce the poultry feed, the factories where the birds are incubated and hatched, the trucks used to transport the chicks, grown chickens and meat, and the factories that butcher the birds and package the meat.
We have developed a new mouse model of aggressive metastatic liver cancer.
In xenograft models of aggressive B-cell lymphoma and MM ABT-263 promoted significant efficacy of clinically relevant chemotherapeutic regimens.
Therefore, therapies guided by preclinical models of aggressive bladder cancers might provide the scientific basis for novel therapies.
Clinical candidate KPT-251 and KPT-330 were also tested in vivo in three models of aggressive PCa.
p48 Cre; LSL- Kras G12D; Cdkn2a f/f (KIC) mice are a well-known preclinical mouse model of aggressive pancreatic ductal adenocarcinoma (PDA).
Sample collection as much as 24 h after death is acceptable for xenograft models of aggressive tumors, despite low cell viability.
We tested a battery of SINE compounds in PCa cell lines and KPT-330 and KPT-251 were tested in vivo using two models of aggressive PCa.
Our previous studies using our NS mouse model of aggressive BPL (Uckun et al., 2015a) exhibited a median survival time of 17 days (standard deviation = 2 days).
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