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Several large studies using standard multivariable modeling have established the importance of molecular matching at HLA-A, B, C, and DRB1 for the outcome of HCT [ 1- 5].
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Agent-Based modeling has established itself as one of these tools.
That and other epidemiological observations, as well as experimental evidence in animal models, have established a clear association between HBV and liver cancer.
Genetically engineered mouse models have established that several PGR-target genes, such as Ihh, Bmp2, Hoxa10, and Hand2, are essential for implantation and decidualization.
Extensive studies using rhodopsin and adrenergic receptors as models have established a general paradigm for GPCR activation.
Conditional transgenic models have established that tumors require sustained oncogene activation for tumor maintenance, exhibiting the phenomenon known as "oncogene-addiction".
Xenograft models have established the efficacy of this compound in both trastuzumab-sensitive and trastuzumab-resistant breast tumors [ 79].
Regression models have established the synergy between social determinants and TB impact indicators, especially TB incidence [ 38].
Furthermore, several studies using mouse models have established convincing links between mutations in certain clock genes and tumorigenesis.
Studies using animal tumour models have established the strong chemopreventive effect of NO-ASA against colon and pancreatic cancer.
Various successful instances of target identification, drug discovery, and disease network reconstruction using humanized yeast models have established its role as a model system for studying human disorders.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com