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Our investigation illustrates some of the advantages of integrating experimentation with modeling for immunological studies.
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Domestic pigs share similarities with humans and represent an excellent animal model for immunological studies.
Zebrafish has been recently recognized as a valuable model for immunological studies [48] since adult zebrafish posses an adaptive and innate immune system similar to mammals [49] [53].
Long-Evans rats may be an appropriate model for immunological studies such as exploring the relationships between leukocyte migration responsiveness, chemokine activity, and uterine activation.
The presence of these well-defined tumour-specific antigens renders MSI-H tumours as a unique model entity for immunological studies.
Multi-agent (or MA) -based design approaches have received much research attention lately for modeling immunological systems due to their efficacy in representing non-heterogeneous behaviors in the population under dynamic environmental and topological conditions.
Although mice constitute the most convenient and versatile model for mechanistic immunological research (plethora of genetically engineered strains and immunological reagents), the tiny size of the murine oral cavity has presented technical challenges for ligature placement.
A recent study reporting the lack of analogous gene array variations between human disease samples and mouse models of three major inflammatory conditions––sepsis, burns and trauma has raised concerns regarding the reliability of mouse models in general for immunological research in defined disease models [ 102].
A relative of T. trichiura that infects mice (T. muris) is a useful laboratory model for study of whipworms and used as a model gastrointestinal nematode for immunological studies (Foth et al. 2014).
Although xenograft models carry limitations for immunological treatment manoeuvers as they do not completely represent the immunological in vivo complexity of interactions between host, tumour, and treatment, a comparative assessment of the antitumour activity of various constructs in our mouse model may help to choose the most promising constructs for clinical translation.
Considering an HIV-RNA threshold of 10,000 copies/mL, which provided in our multivariate model the best prognostic value for immunological response, elevated HIV-RNA levels were always associated with impaired immune reconstitution.
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Justyna Jupowicz-Kozak
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