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In this early forward modeling approach, determination of parameters was done manually.
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Combining both types of modeling approach enabled determination that the drug was incapable of reaching the edge of the hypoxic region of the tumor, partially due to consumption of the drug as it diffused into the tumor.
The modeling approach has enabled determination of the effect of vapor processing variables such as flux orientation, deposition rate and substrate temperature on deposit morphology/microstructure as defined by packing density, surface roughness and growth column width (which appears closely related to grain size).
An atomistic modeling approach is applied for the determination of the role of each element and identification of the interactions and features responsible for the transition to the high entropy regime.
The problem is addressed with a numerical modeling approach (landscape evolution model, hereafter LEM) that requires empirical determinations of parameters and threshold values.
To demonstrate the power of such a bottom-up modeling approach combined with a systemic parameter determination, we used the simple and well understood photosynthetic apparatus of the purple bacterium Rhodobacter (Rb).
Figure 4 Determine unknown model point coordinate (relative modeling approach).
Besides application of the integrative dynamic model to study whole-cell metabolism during batch and fed-batch processes, the modeling approach can be used for in silico determination of the optimal operating conditions, such as feed rate or feed medium composition, for fed-batch fermentation of lignocellulosic hydrolysate (Unrean and Franzen 2015).
This modeling approach reduces the modeling uncertainty.
These two models use the same modeling approach.
A modeling approach, 'nicotine bridging', was developed based on the determination of nicotine exposure in clinical evaluations which indicated that exposure to HPHC for which biomarkers of exposure do not exist would also be reduced.
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