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We have introduced and evaluated a new computational approach to represent combinatorial patterns of epigenetic marks as quantitative variables suitable for predictive modeling and supervised machine learning.
For linear modeling and supervised inferences, we used the package "limma" [ 62].
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Differences in contrasts of interest were analyzed statistically by unsupervised and supervised modeling approaches, namely Principal Component Analysis and Linear Model of analysis of variance.
I.M.: designed and supervised experiments.
A.W.: designed and supervised experiments.
She trained and supervised numerous therapists.
C.Ä.: designed and supervised experiments and finalized the manuscript.
T.K., D.Z. and A.W. designed protocols and supervised data collection.
SV designed and supervised meal administration, wrote/edited the manuscript.
All analyses were conducted by O.F.B. and supervised by I.M.G.
H.Y. designed the project and supervised data analysis.
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