This chapter deals with modeling and remodeling of the bone.
However, modeling and remodeling of BMP-induced bone have rarely been discussed.
However, it remains to be shown how microgravity affects the expression of genes involved in modeling and remodeling of bone material in vivo.
The purpose of modeling and remodeling during growth is to optimize bone strength by depositing bone where it is needed and to minimize mass by removing it from where it is not needed.
The purpose of modeling and remodeling during adulthood is simply to maintain bone strength by damage repair but four age-related changes compromise bone's material composition and structure; a decline in periosteal bone formation, a decline in the volume of bone formed by each basic multicellular unit (BMU), continued resorption by each BMU, and high remodeling.
The delayed ossification persists into adulthood and is accompanied by impaired bone modeling and remodeling, resulting in short stature, increased bone mass, and gross morphologic abnormalities of the bones and joints, but normal bone strength.
Perhaps if the researcher has early in vitro data showing biocompatibility of the scaffold, the animal study will have different time intervals that demonstrate the healing process through early response, modeling, and remodeling processes.
The cell-matrix and cell-cell interactions regulate continuous PDL turnover, modeling and remodeling of bone, and subsequent adaptation of primary and secondary cementum, including PDL-bone and PDL-cementum interfaces throughout their physiological function [ 2– 5].
More active and extensive bone modeling and remodeling suggest that accelerated tooth movement associated with augmented corticotomy is due to increased bone turnover and RAP [ 35], as shown by our results.
