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Description: Develops theoretical basis for modeling and quantitative analysis of biological problems.
The observed uncertainties in the hydrological forecasts were shown to originate from both the insufficient quality of precipitation forecasts as well as deficiencies in hydrological modeling and quantitative precipitation estimation.
There is a growing interest in the field of modeling and quantitative assessment of environmental problems.
Interdisciplinary and multi-agency initiatives, such as NSF's IGERT and a new partnership between NIH and NSF, promise to advance biology through the use of modeling and quantitative methods.
Using a combination of modeling and quantitative experiments, we show that the PAE can be explained by the temporal dynamics of drug detoxification in individual cells after an antibiotic is removed from the extracellular environment.
For modeling and quantitative predictions, all these changes, and their interdependence, will need quantification.
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These methods typically fall into four classes: methods combining quantum mechanics and molecular mechanics (QM/MM), pure molecular mechanics-based methods – a class which can be subdivided into static and dynamic transition state modeling – and lastly quantitative structure selectivity relationship methods (QSSR).
Such a modeling approach is generally known as Quantitative Structure-Activity Relationship (QSAR) approach, with the special QSAR case here being the Quantitative Structure-Pharmacokinetic Relationship (QSPkR) modeling [11,12].
Taking hard disk drives as a typical example of high-precision servo systems, this paper focuses on servo system modeling and reduction through quantitative analysis using finite element method.
Here, we briefly discuss this foundational work and survey recent efforts combining targeted biochemical perturbations and quantitative modeling to specifically address the diverse roles that phase separation processes may play in biology.
As the first, fully integrated and quantitative modeling environment for the study of ion transport dynamics in a plant cell, OnGuard offers a unique tool for exploring homeostatic properties emerging from the interactions of ion transport, both at the plasma membrane and tonoplast in the guard cell.
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