Sentence examples for modeling and mechanistic from inspiring English sources

These isogenic TAU-iPSC lines represent a critical advancement toward the accurate modeling and mechanistic study of tauopathies with human neurons and will be invaluable for drug-screening efforts and future cell-based therapies.

Complementary information from multiple assays, pharmacokinetic modeling and mechanistic follow-up studies are necessary components of the overall framework.

Thus, the use of computer modeling and mechanistic toxicology for the development of a predictive tool is a promising approach to deal with chemical mixtures.

We thus present a comprehensive study of selection at synonymous sites in mammalian rhodopsin incorporating both substitution rate modeling, and mechanistic lines of evidence for selection pressures related to translational processes.

Although our original aim was to use the diffusion model as a descriptive tool to jointly capture patterns in mean choice, response times and neural activity (rather than to claim the superiority of the diffusion model over more realistic counterparts), we do agree that mechanistic modeling and model comparison issues can and should be addressed in a separate paper.

These results demonstrate that we can use modeling to identify key areas of uncertainty and suggests strategies to reduce uncertainty in the trial outcome by refining the model parameters and mechanistic understanding.

Figure 1 Two approaches for modeling habitat suitability: (a) correlative modeling, and (b) mechanistic modeling approaches (adopted from Kearney[2006]).

In order to develop a general and mechanistic modeling framework for non-linear analysis of low-cycle damage in cemented materials, this paper presents a cracked-hinge model aimed at the analysis of the bending fracture of the cemented material.

The goal of this paper is, using a combination of field data and mechanistic modeling results, to evaluate and compare the spatial effectiveness of improvements in ISOS and introduction of VFS to reduce surface runoff pollution in the semi-arid/arid furrow irrigation agroecosystem that exceeds current regulatory turbidity limits (25 NTU).

Bäckman presented clinical PK data and mechanistic modeling data on a selective glucocorticoid modulator Hochhaus presented some thoughts on how this might work for an ICS, and Niven extended the discussion to atypical molecules.

There is a need for improved paleoclimate models, improved paleoclimate proxy and species paleodistribution data for model validation, attention to scale issues, and rigorous modeling methods including mechanistic models.