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Structural modeling and energetic analysis of cancer mutation effects can provide further insights into molecular mechanisms of kinase activation.
Furthermore, structural modeling and energetic analysis of kinase cancer mutations, which constitute the largest mutational hotspot, have provided useful insights into a common mechanism of kinase activation.
Structural modeling and energetic analysis of the mutational hotspots have suggested a common molecular mechanism of kinase activation by cancer mutations, and have allowed to reconcile the experimental data.
Structural modeling and energetic analysis of the mutational hotspots have also suggested a common molecular mechanism of kinase activation by cancer mutations, which may be determined by a combined effect of the partial destabilization of the inactive state and a concomitant stabilization of the active-like form of the enzyme.
The major structure of (GACG AGUGUCA 2 is novel and suggests that homology modeling and energetic calculations of RNA may need to consider interactions beyond nearest neighbors.
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The problem of modeling solar energetic particle (SEP) events is important to both space weather research and forecasting, and yet it has seen relatively little progress.
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