In the model, action potentials onto inhibitory cells represent input from other brain areas and desynchronize network activity, being crucial for the emergence of amplitude fluctuations.
In the classic HH model, action potentials are generated through the interaction of a leak current and two voltage-gated ionic currents, carried by a sodium ion specific channel and a potassium ion specific channel.
This suggests a reasonable model that action potentials open VGCC leading to a transient increase in cytoplasmic Ca, which in turn modulates these KCa.
In neuroscience it is difficult to overstate the importance of the Hodgkin–Huxley model of action potentials or Rall's use of cable theory to provide a framework for understanding the complex, dendritic structures of neurons.
The study by Frommeyer et al. in this issue of the European Journal of Heart Failure adds to the existing body of evidence and expands previous work by that group by using a rabbit heart failure model investigating action potentials mapped from the epicardium of isolated Langendorff-perfused rabbit hearts ex vivo.
Modelling the individual action potentials of neurons may therefore provide a mechanism beyond the scope of rate-coded models to both overcome the binding problem through 'feature-linking' (Gray et al. 1989) and simultaneously segment different stimuli within the same scene.
This generic ventricular model approximates well the restitution properties and spiral wave behavior of more complex ionic models of cardiac action potentials.
Integrating these empirical results in computational models of action potential dynamics at the membrane of a cortical neuron, we specify the functional effects of the mutation and describe a mechanism that leads to temperature-sensitive epilepsy.
Some of the more powerful examples are the Hodgkin-Huxley model of action potential propagation, Hebbian-based plasticity rules, Barlow's efficient coding hypothesis and Marr's three levels of analysis.
For example, in neuron models, the action potential changes on a much faster time scale than ionic gating variables.
MMOs are a class of complex oscillations occurring in excitable systems and in particular in models of action potential generation in neurons, see [21] for a review.
