This supports the validity of the approach as expression of mutant human proteins in C. elegans can closely model a fundamental property of these mutations in humans.
These similarities strongly argue that the mutant human proteins, when expressed in C. elegans, are closely modelling a fundamental property of these mutations in humans.
All these considerations are accounted for in the Grand Product Design Model, which consists of a process model, a property model, a quality model, a cost model, a pricing model, an economic model as well as factors such as company strategy, government policies and regulations.
It is notable that SKI-356313 has potent growth inhibitory properties against nonreplicating M. tuberculosis in the Wayne model, a property that holds potential for the development of a novel, shorter TB drug regimen through the targeting of persistent bacteria.
Similarly, novel H1N1 is highly virulent in animal models, a property linked to its ability to replicate efficiently in the lungs [ 32], and likely attributable to lack of glycosylation.
This comparison reveals that the wild-type fission yeast spindles are substantially stronger than the random model; a property that also applies to the cdc25.22 and the majority of budding yeast spindles.
Despite this ubiquitous parametric uncertainty, key temporal outputs are typically robust to large changes in most parameters for this class of systems biology models, a property called "sloppiness" that, to some extent, mitigates the problem that unidentifiable parameters cause, with respect to reproducing biologically relevant behavior.
Being able to model a key ocean property driving the AMOC lets them forecast the current's behavior not months but years into the future.
The advantages of our approach is that developers do not have to model how the devices interact to achieve the objectives (i.e., decision making) and do not need to modify the model when a property is not satisfied.
We interpret this multiplicity of models as a property of the fiber itself: there is a multiplicity of fiber structures!
