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Based on the 3D structures of complexes in the target pathway and a protein protein interaction modeling tool which allows accurate and proteome-scale applications, we modeled the structures of 29 interactions, 21 of which were previously unknown.
First we modeled the structures of 10 proteins and then provided models for 40 additional interactions.
We modeled the structures of WT and TP/LP peptides and conducted molecular dynamics simulations in water solvent.
However, since there is significant sequence homology of these proteins with LipA, we modeled the structures of these proteins using RaptorX.
As a validation step, we modeled the structures of the mutated sequences in order to compare the change in the electrostatic profile.
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To further investigate CAM2, we modeled the structure of CAM2_204.
We then modeled the structure of the human UGT1A1 by using the SWISS-MODEL [ 78].
We modeled the structure of the complexes formed by the mSMO enzyme with BENSpm and CPENSpm.
Modeling the structures of individual PCSK enzymes has offered little insights into the specificity determinants.
One way forward is to model the structure of these proteins using similarity modelling methods.
In 1917, Einstein applied the general theory of relativity to model the structure of the universe as a whole.
Related(15)
explored the structures
developed the structures
investigated the structures
designed the structures
influenced the structures
template the structures
analyzed the structures
demonstrated the structures
modeled the structured
modeled the stripes
modeled the data
modeled the clothes
modeled the legs
modeled the principles
modeled the structure
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