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Mechanistic understanding of FA draws insight from a myriad of atopic conditions studied in humans and modeled in mice.
Features of alcoholism, such as alcohol dependence, tolerance, and impaired control over alcohol drinking have been successfully modeled in mice.
That said, the result that the debunking analyses propose remains implausible: antidepressants help in severe depression, depressive subtypes, chronic minor depression, social unease and a range of conditions modeled in mice and monkeys — but uniquely not in isolated episodes of mild depression in humans.
The great hope, he says, is that the technique will one day lead to primate models of "schizophrenia and other neuropsychiatric diseases that are not easily modeled in mice".
These assays will be suitable to assist in the characterization of cancer and other diseases modeled in mice that are associated with altered expression of cystatin genes.
The role of PI3K signaling in prostate cancer has been modeled in mice by deletion of PTEN or by transgenic expression of activated AKT, while the role of MYC has been investigated by transgenic expression of MYC.
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Human GBM was modelled in mice by intracranial implantation of U87MG.EGFRvIII cells.
Prion disease is modelled in mice through ME7 prion agent infection resulting in both a behavioural phenotype and synaptopathy [ 44].
We are therefore now able to model in mice three strong breast cancer susceptibility syndromes of humans.
Recent studies have reported on the use of multiplexed cytokine analysis coupled with multivariate regression modeling in mouse models of inflammation, e.g. colitis [34], [35].
The degree to which all aspects of JBTS have or even can be modelled in mouse is difficult to assess.
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