To obtain the 3D reconstruction of the SWR1-nucleosome complex, we first refined our apo-SWR1 model, obtained by refining the OTR model against 2D class averages of apo-SWR1, against 2D class averages generated from the SWR1-nucleosome data.
These models are constructed by refining a model with an arbitrary initial connectivity.
The final model was created by refining the consensus model with molecular dynamics simulations.
It seems that further improvement of the model could be made by refining the latitude dependencies of coefficients used for the transport term.
It is also often difficult to identify studies extending the results of previous mapping studies by refining model specification, conducting external validation or developing tools to estimate predictions.
The main objective of this study is to address this issue by refining the modelling practices to simulate some reactive processes of interest, while acknowledging the uneven contact time stemming from the RTD curves.
Joint calibration strategies address this issue by refining hydrological model parameters jointly with the autoregressive (AR) model.
We will reduce these costs further by refining the model.
Further model development would be aided by refining acoustic target information and applying complimentary fish sampling gears (i.e., split-beam fisheries acoustics gear, underwater video).
By refining this model through further study, we aim to more effectively target metacognitive development in undergraduate biology students.
