We also ran models adjusted for the intake of several nutritional factors that may be associated with BPb and BP, including both serum and dietary (in separate models) calcium, iron, potassium, and sodium (modeled as continuous variables calculated from laboratory values, for serum levels, and calculated values from dietary intake questionnaires, for dietary levels).
Hb >12 g/dL and Hb <10 g/dL were modeled as binary outcomes, and ferritin, TSat, and EPO dose were modeled as continuous outcomes.
In a second set of analyses, multiple linear regression models were used to explore differences in CVD risk factors (modeled as continuous variables) between case and control youth.
Interactions between BMI and FTO rs9939609, both modeled as continuous variables (0, 1 and 2 for the FTO alleles), were investigated.
Adjusted estimates for the number of previously failed regimen modeled as continuous variables indicated a steeper association with virological failure in patients from the cART era compared to the mono/dual era: odds ratio per previous regimen failed of 1.87 (95% CI 1.58 2.21) vs. 1.49 (1.49–1.49).
Age at menarche modeled as continuous.
All temperature measurements were modeled as continuous variables.
In the primary analyses, ambient and apparent temperature were modeled as continuous linear functions.
p-Values for trend (ptrend) were estimated with arsenic exposure variables modeled as continuous variables.
The distribution of IM-ITE percentile scores and years of RRC certification were approximately normal, and modeled as continuous outcomes.
